Joshua Johnson

Joshua Johnson

Research laboratory at the CU-Anschutz School of Medicine | DRS | REI | Basic/translational studies of the mammalian ovary

Posts by Collection

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publications

Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood

Published in Cell, 2005

Recommended citation: Johnson, J., Bagley, J., Skaznik-Wikiel, M., Lee, H.-J., Adams, G.B., Niikura, Y., Tschudy, K.S., Canning Tilly, J., Cortes, M. L., Forkert, R., Spitzer, T., Iacomini, J., Scadden, D.T., Tilly, J.L. (2005). "Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood." Cell. 122, 303-315. http://linkinghub.elsevier.com/retrieve/pii/S0092-8674(05)00650-1

mTOR kinase inhibition results in oocyte loss characterized by empty follicles in human ovarian cortical strips cultured in vitro

Published in Fertility and Sterility, 2011

Recommended citation: McLaughlin, M., Patrizio, P., Kayisli, U., Luk, J., Anderson, R., Thomson, T.C., Telfer, E., Johnson, J. (2011). "mTOR kinase inhibition results in oocyte loss characterized by empty follicles in human ovarian cortical strips cultured *in vitro*." Fertility and Sterility. 96, 1154-1159.e1. http://www.sciencedirect.com/science/article/pii/S0015028211024915

Knockdown of HoxA11 In Vivo in the Uterosacral Ligament and Uterus of Mice Results in Altered Collagen and Matrix Metalloproteinase Activity

Published in Biology of Reproduction, 2012

Recommended citation: Ma, Y., Guess, M., Datar, A., Hennessey, A., Cardenas, A., Johnson, J., Connell, K. (2012). "Knockdown of *HoxA11 In Vivo* in the Uterosacral Ligament and Uterus of Mice Results in Altered Collagen and Matrix Metalloproteinase Activity." Biology of Reproduction. 86, 1-8. http://www.biolreprod.org/content/early/2011/12/16/biolreprod.111.093245.full.pdf+html

Granulosa Cell and Oocyte Mitochondrial Abnormalities in a Mouse Model of Fragile X Primary Ovarian Insufficiency

Published in Molecular Human Reproduction, 2016

Recommended citation: Conca Dioguardi, C., Uslu, B., Haynes, M., Kurus, M., Gul., M., Miao, D-Q., De Santis, L., Ferrari, M., Bellone, S., Santin, A., Giulivi, C., Hoffman, G., Usdin, K., Johnson, J. (2016). "Granulosa Cell and Oocyte Mitochondrial Abnormalities in a Mouse Model of Fragile X Primary Ovarian Insufficiency." Molecular Human Reproduction. 10, 1-11. http://molehr.oxfordjournals.org/content/22/6/384.long

Reduction in FSH throughout the menstrual cycle after Omega-3 Fatty Acid supplementation in young normal weight but not obese women

Published in Reproductive Sciences, 2019

Recommended citation: Bauer, J.L., Kuhn, K., Bradford, A.P., Al-Safi, Z.A., Harris, M.A., Eckel, R.H., Robledo, C.Y., Malkhasyan, A., Johnson, J., Gee, N.R., Polotsky, A.J. (2019) "Reduction in FSH throughout the menstrual cycle after Omega-3 Fatty Acid supplementation in young normal weight but not obese women"Reproductive Sciences, 26, 8: 1025-1033. https://journals.sagepub.com/doi/full/10.1177/1933719119828099

Basal Characterization and In Vitro Differentiation of Stem Cells Derived from the Adult Mouse Ovary.

Published in In Vitro Cellular & Developmental Biology-Animal, 2020

Recommended citation: Majidi Zolbin, M., Sahin Ersoy, G., Aliakbari, F., Amidi, F, Daghigh, F, Abbasi, M., Johnson, J. (2020) Basal Characterization and In Vitro Differentiation of Stem Cells Derived from the Adult Mouse Ovary. In Vitro Cellular \& Developmental Biology-Animal, 56, 59-66. https://link.springer.com/article/10.1007/s11626-019-00411-x

Effect of neuronal nitric oxide synthase serine-1412 phosphorylation on hypothalamic-pituitary-ovarian function and the neuroendocrine leptin response.

Published in Biology of Reproduction, 2020

Recommended citation: Guerra, D.D., Bok, R., Llerena Cari, E., Nicholas, C., Orlicky, D.J., Johnson, J., Hurt, K.J. (2020) Effect of neuronal nitric oxide synthase serine-1412 phosphorylation on hypothalamic-pituitary-ovarian function and the neuroendocrine leptin response. Biology of Reproduction, 102, 6:1281-1289. https://academic.oup.com/biolreprod/article-abstract/102/6/1281/5758286

PREPRINT OF MANUSCRIPT ACCEPTED FOR PUBLICATION 10/22: Expression and T-cell Regulatory Action of the PD-1 Immune Checkpoint in the Ovary and Fallopian Tube.

Published in bioRxiv, 2020

Recommended citation: Johnson, J., Sam, P.K., Rengasamy, A., Perez, L., Llerena Cari, E., Bales, C.E., Kallen, A., Nel-Themaat, L., Polotsky, A.J., Post, M., Orlicky, D., Jordan, K., Bitler, B. Expression and T-cell Regulatory Action of the PD-1 Immune Checkpoint in the Ovary and Fallopian Tube. Manuscript submitted for publication; preprint available at bioRxiv, DOI: 138123, 2020. https://www.biorxiv.org/content/10.1101/2020.06.06.138123v1

Using the Novel Pelvic Organ Prolapse Histology Quantification System (POP-HQ) to Identify Phenotypes in Uterosacral Ligaments in Women with Pelvic Organ Prolapse.

Published in American Journal of Obstetrics & Gynecology, 2021

Recommended citation: Orlicky, D., Guess, M.K., Bales, C.E., Rascoff, L., Arruda, J.S., Hutchinson-Colas, J., Johnson, J., Connell, K.A. (2021) Using the Novel Pelvic Organ Prolapse Histology Quantification (POP-HQ) System to Identify Phenotypes in Uterosacral Ligaments in Women with Pelvic Organ Prolapse. AJOG, 224: 67.e1-67.e18 https://www.sciencedirect.com/science/article/abs/pii/S0002937820312709

Integrated Stress Response Control of Granulosa Cell Translation and Proliferation During Normal Ovarian Follicle Development: Molecular Human Reproduction EDITOR’S CHOICE Article.

Published in Molecular Human Reproduction, 2021

Recommended citation: Llerena Cari, E., Hagen-Lillevik, S., Giornazi, A., Post, M., Komar, A.A., Appiah, L., Bitler, B., Polotsky, A.J., Santoro, N., Kieft., J, Lai, K., Johnson, J. Volume 27, Issue 8, August 2021, Molecular Human Reproduction https://doi.org/10.1093/molehr/gaab050

ATF6-mediated signaling contributes to PARP Inhibitor Resistance in Ovarian Cancer.

Published in Molecular Cancer Research, 2022

Recommended citation: McMellen, A., Yamamoto, T.M., Qamar, L., Sanders, B.E., Nguyen, L.L, Ortiz Chavez, D., Bapat, J., Berning, A., Post, M.D., Johnson, J., Behbakht, K., Nurmemmedov, E., Bitler, B.G. (2023) ATF6-mediated signaling contributes to PARP Inhibitor Resistance in Ovarian Cancer. Molecular Cancer Research, 21(1): 3–13. https://doi.org/10.1158/1541-7786.MCR-22-0102

Expression and T-cell Regulatory Action of the PD-1 Immune Checkpoint in the Ovary and Fallopian Tube.

Published in American Journal of Reproductive Immunology, 2022

Recommended citation: Johnson, J., Kim, S-Y., Sam, P.K., Rengasamy, A., Perez, L., Llerena Cari, E., Bales, C.E., Kallen, A., Nel-Themaat, L., Polotsky, A.J., Post, M., Orlicky, D., Jordan, K., Bitler, B. (2022) Expression and T-cell Regulatory Action of the PD-1 Immune Checkpoint in the Ovary and Fallopian Tube. American Journal of Reproductive Immunology, 89(3), e13649. https://doi.org/10.1111/aji.13649

Estrogen and Androgen Receptor Status in Uterosacral Ligaments of Women with Pelvic Organ Prolapse stratified by the Pelvic Organ Prolapse Histology Quantification System.

Published in Reproductive Sciences, 2023

Recommended citation: Orlicky, D., Smith, E.E., Bok, R., Guess, M., Rascoff, M.G., Arruda, J.S., Hutchinson-Colas, J.A., Johnson, J., Connell, K.A. Estrogen and Androgen Receptor Status in Uterosacral Ligaments of Women with Pelvic Organ Prolapse stratified by the Pelvic Organ Prolapse Histology Quantification System. Reproductive Sciences. 10.1007/s43032-023-01283-z (2023). https://link.springer.com/article/10.1007/s43032-023-01283-z

talks

Ovarian Follicle Dynamics

Published:

Provided a brief survey of the field and original data on the development of individual ovarian follicles within dynamic population(s).

In Vitro Derived Oocytes

Published:

Co-leader of expert working group, developing position paper on the state-of-the-science and practicality of generating human eggs in vitro.

Primordial Follicle Growth Activation

Published:

Presentation for Division of Reproductive Endocrinology and Infertility Fellows on the genetics and biochemical/signaling regulation of primordial follicle growth activation.

Physiological Compromise in Carriers of The Fragile X Premutation: Lessons from the Ovary

Published:

A ‘general research interests’ talk for the UC-Denver Integrated Physiology Graduate Program, with focus on our work on Fragile X Premutation. I will cover recent progress in studying basic follicle development and survival, challenges in quantifying ovarian follicles, and the interface between reproductive physiology and reproductive medicine.

Controlling the Rate of Primordial Ovarian Follicle Growth Activation

Published:

Designed an accepted Minisymposium on this topic for the 2019 Paris Society for Reproductive Investigation Meeting (Paris, France). Co-speakers included Dr. Amanda Kallen (Yale University School of Medicine), Celine Guigon, PhD (University of Paris Diderot-CNRS), and Francesca Duncan (Northwestern University).

Gene Profiling in Uterosacral Ligaments in Premenopausal Women with Prolapse

Published:

Dr. Kathleen Connell, Division Director of the Division of Urogynecology and Pelvic Floor Reconstructive Surgery, presented these data on behalf of co-authors Johnson, J., Guess, M.K., Rascoff, L., Orlicky, D., Bales, E.S., Arruda, J., Kumar, R. This lecture is included because this collaborative abstract was awarded the best basic science abstract and presented in the plenary opening session at the AUGS/IUGA Joint Scientific Meeting.

Ovarian Recovery in Cancer Survivorship. Keynote Lecture

Published:

This lecture for a fertility preservation provider audience provided a backdrop of basic and translational ovarian biology. In it, we asked the question: when we cryopreserve patient ovarian cortex, what is it that needs to “go right” so ovarian function recovers? So that the patient has the highest chances for ongoing ovarian function and potential conception? Special consideration was given to potentially compromised ovarian function due to the underlying cancer.

teaching